Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness

作者: Emmanuel Chautard , Zangbéwendé Guy Ouédraogo , Julian Biau , Pierre Verrelle

DOI: 10.1007/S11060-014-1382-9

关键词:

摘要: … Akt signaling pathway plays an important role in glioma progression and aggressiveness. Among Akt … two other isoforms, Akt2 and Akt3 have emerged in glioma. After a description of …

参考文章(114)
Moscatello Dk, Wong Aj, Wong My, McDanel H, Montgomery Rb, Sundareshan P, Transformational and altered signal transduction by a naturally occurring mutant EGF receptor. Oncogene. ,vol. 13, pp. 85- 96 ,(1996)
Jaclyn LoPiccolo, Courtney A. Granville, Phillip A. Dennis, Joell J. Gills, Targeting Akt in cancer therapy. Anti-Cancer Drugs. ,vol. 18, pp. 861- 874 ,(2007) , 10.1097/CAD.0B013E3280CC2C6F
Alfonso Bellacosa, C. Chandra Kumar, Antonio Di Cristofano, Joseph Robert Testa, Activation of AKT kinases in cancer: implications for therapeutic targeting. Advances in Cancer Research. ,vol. 94, pp. 29- 86 ,(2005) , 10.1016/S0065-230X(05)94002-5
Binhua P. Zhou, Yong Liao, Weiya Xia, Yiyu Zou, Bill Spohn, Mien-Chie Hung, HER-2 / neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation Nature Cell Biology. ,vol. 3, pp. 973- 982 ,(2001) , 10.1038/NCB1101-973
Ken D. Aldape, Russell O. Pieper, Tomoko Ozawa, Mitchel S. Berger, Dennis F. Deen, Yukihiko Sonoda, Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma Cancer Research. ,vol. 61, pp. 6674- 6678 ,(2001)
Osman Nidai Ozes, Lindsey D Mayo, Jason A Gustin, Susan R Pfeffer, Lawrence M Pfeffer, David B Donner, None, NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase Nature. ,vol. 401, pp. 82- 85 ,(1999) , 10.1038/43466
Ronald L. Hamilton, Marina N. Nikiforova, Molecular diagnostics of gliomas. Archives of Pathology & Laboratory Medicine. ,vol. 135, pp. 558- 568 ,(2011) , 10.1043/2010-0649-RAIR.1
JUN‐PING LIU, Studies of the molecular mechanisms in the regulation of telomerase activity The FASEB Journal. ,vol. 13, pp. 2091- 2104 ,(1999) , 10.1096/FASEBJ.13.15.2091
Mark De Ridder, Valeri N. Verovski, Martine I. Darville, Dirk L. Van Den Berge, Christinne Monsaert, Decio L. Eizirik, Guy A. Storme, Macrophages enhance the radiosensitizing activity of lipid A: a novel role for immune cells in tumor cell radioresponse. International Journal of Radiation Oncology Biology Physics. ,vol. 60, pp. 598- 606 ,(2004) , 10.1016/J.IJROBP.2004.05.065