AEG-1-AKT2: A novel complex controlling the aggressiveness of glioblastoma.
作者： Luni Emdad , Bin Hu , Swadesh K Das , Devanand Sarkar , Paul B Fisher
DOI: 10.4161/23723556.2014.995008
关键词:
摘要: Expression of AEG-1 (also known as MTDH or LYRIC) is elevated in many cancers including glioblastoma multiforme (GBM), which it functions an oncogene. activates AKT signaling and physically interacts with AKT2 GBM. Disruption this interaction reduces glioma cell survival invasion, uncovering a novel potential target for development effective therapy against
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