Nucleolar and spindle-associated protein 1 is a tumor grade correlated prognosis marker for glioma patients.
作者： Tao Zhu , Pan Xie , Yuan-Feng Gao , Ma-Sha Huang , Xi Li
DOI: 10.1111/CNS.12803
关键词:
摘要: Aims Despite therapeutic advances in glioma management including surgery, radiation, and chemotherapy, the improvement of patient outcome is far from satisfactory. Nucleolar spindle-associated protein 1 (NUSAP1) an important functional during mitosis, its abnormal expression implicated progression different types tumors. However, role NUSAP1 gliomas remains unclear. Methods with grades was investigated based on GEO datasets. Kaplan-Meier survival analysis used to evaluate prognostic significance. In vitro assays were also performed effects malignant phenotypes cells by silencing NUSAP1. Results correlated not only grade but prognosis patients. depletion suppressed proliferation U251 inducing cell cycle arrest at G2/M phase apoptosis. rendered impaired migratory ability as well. Conclusion a potential marker for patients strategies targeting might hold promise improving treatment.
sci-hub.se 参考文章(36)
Masayuki Kanamori, Hiroyoshi Suzuki, Hidehiro Takei, Yukihiko Sonoda, Hiroshi Uenohara, Teiji Tominaga, Malignant transformation of diffuse astrocytoma to glioblastoma associated with newly developed BRAF V600E mutation Brain Tumor Pathology. ,vol. 33, pp. 50- 56 ,(2016) , 10.1007/S10014-015-0231-7
Gholamreza Bidkhori, Zahra Narimani, Saman Hosseini Ashtiani, Ali Moeini, Abbas Nowzari-Dalini, Ali Masoudi-Nejad, Reconstruction of an Integrated Genome-Scale Co-Expression Network Reveals Key Modules Involved in Lung Adenocarcinoma PLoS ONE. ,vol. 8, pp. e67552- ,(2013) , 10.1371/JOURNAL.PONE.0067552
K. S. Aboody, A. Brown, N. G. Rainov, K. A. Bower, S. Liu, W. Yang, J. E. Small, U. Herrlinger, V. Ourednik, P. McL. Black, X. O. Breakefield, E. Y. Snyder, Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 12846- 12851 ,(2000) , 10.1073/PNAS.97.23.12846
Luni Emdad, Bin Hu, Swadesh K Das, Devanand Sarkar, Paul B Fisher, AEG-1-AKT2: A novel complex controlling the aggressiveness of glioblastoma. Molecular and Cellular Oncology. ,vol. 2, ,(2015) , 10.4161/23723556.2014.995008
Byungwoo Ryu, Dave S. Kim, Amena M. DeLuca, Rhoda M. Alani, Comprehensive Expression Profiling of Tumor Cell Lines Identifies Molecular Signatures of Melanoma Progression PLoS ONE. ,vol. 2, pp. e594- ,(2007) , 10.1371/JOURNAL.PONE.0000594
Shweta Kotian, Tapahsama Banerjee, Ainsley Lockhart, Kun Huang, Umit V Catalyurek, Jeffrey D Parvin, NUSAP1 influences the DNA damage response by controlling BRCA1 protein levels Cancer Biology & Therapy. ,vol. 15, pp. 533- 543 ,(2014) , 10.4161/CBT.28019
Lu Li, Ying Zhou, Libo Sun, Guichun Xing, Chunyan Tian, Jing Sun, Lingqiang Zhang, Fuchu He, NuSAP is degraded by APC/C–Cdh1 and its overexpression results in mitotic arrest dependent of its microtubules' affinity Cellular Signalling. ,vol. 19, pp. 2046- 2055 ,(2007) , 10.1016/J.CELLSIG.2007.05.017
Franco M. Recchia, Lili Xu, John S. Penn, Braden Boone, Phillip J. Dexheimer, Identification of genes and pathways involved in retinal neovascularization by microarray analysis of two animal models of retinal angiogenesis. Investigative Ophthalmology & Visual Science. ,vol. 51, pp. 1098- 1105 ,(2010) , 10.1167/IOVS.09-4006
N. Smets, K. Moermans, M. Dewerchin, P. Carmeliet, G. Carmeliet, A. Vanden Bosch, T. Raemaekers, S. Denayer, S. Torrekens, NuSAP is essential for chromatin-induced spindle formation during early embryogenesis Journal of Cell Science. ,vol. 123, pp. 3244- 3255 ,(2010) , 10.1242/JCS.063875
K. A. Jaeckle, P. A. Decker, K. V. Ballman, P. J. Flynn, C. Giannini, B. W. Scheithauer, R. B. Jenkins, J. C. Buckner, Transformation of low grade glioma and correlation with outcome: an NCCTG database analysis Journal of Neuro-oncology. ,vol. 104, pp. 253- 259 ,(2011) , 10.1007/S11060-010-0476-2