The role of oxygen availability in embryonic development and stem cell function
作者： M. Celeste Simon , Brian Keith
DOI: 10.1038/NRM2354
关键词:
摘要: Low levels of oxygen (O2) occur naturally in developing embryos. Cells respond to their hypoxic microenvironment by stimulating several hypoxia-inducible factors (and other molecules that mediate O2 homeostasis), which then coordinate the development blood, vasculature, placenta, nervous system and organs. Furthermore, embryonic stem progenitor cells frequently occupy 'niches' low regulates differentiation. Recent work has revealed an important link between are involved regulating cell behaviour factors, provides a molecular framework for control differentiation fate. These findings have implications therapies tissue regeneration disease.
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