Secondary narcolepsy may be a causative factor of increased daytime sleepiness in obese childhood craniopharyngioma patients.

摘要: Prognosis in childhood craniopharyngioma survivors hinges upon late effects such as pituitary deficiency and obesity. Observations indicate that reduced physical activity increased daytime sleepiness might be risk factors for We analyzed the degree of 115 patients (47% obese) using Epworth Sleepiness Scale (ESS). Thirty-five (30%) displayed (ESS score > 10) whom 14 were obese (26% cohort). Polysomnography (PSG) Multiple Sleep Latency Tests (MSLT) conducted with 10 presenting sleepiness, only two revealing a sleep related breathing disorder. Four had repeated episodes SOREM (sleep onset rapid eye movement), classic PSG criterion narcolepsy. Three hypersomnia. All but one patient qualified acutely obese. speculate secondary narcolepsy is an exacerbating condition obesity, supported by recent reports on orexin which suggest hypothalamic failure idiopathic