Use of a Glutaric Acid Cocrystal to Improve Oral Bioavailability of a Low Solubility API
作者： Daniel P. McNamara , Scott L. Childs , Jennifer Giordano , Anthony Iarriccio , James Cassidy
DOI: 10.1007/S11095-006-9032-3
关键词:
摘要: Purpose The bioavailability of a development candidate active pharmaceutical ingredient (API) was very low after oral dosing in dogs. In order to improve bioavailability, we sought to …
springer.com
sci-hub.se 
researchgate.net 参考文章(27)
Mino R. Caira, Theo G. Dekker, Wilna Liebenberg, Structure of a 1:1 complex between the anthelmintic drug mebendazole and propionic acid Journal of Chemical Crystallography. ,vol. 28, pp. 11- 15 ,(1998) , 10.1023/A:1021766300133
Walter C. McCrone, Fusion methods in chemical microscopy Interscience Publishers. ,(1957)
James A. Ibers, Lonsdale, Kathleen, Dame, John S. Kasper, Gerard D. Rieck, Walter C. Hamilton, Norman Fordyce McKerron Henry, Caroline H. MacGillavry, International tables for X-ray crystallography UT Back-in-Print Service. ,(1962)
Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah, John R. Crison, A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability Pharmaceutical Research. ,vol. 12, pp. 413- 420 ,(1995) , 10.1023/A:1016212804288
Joel Bernstein, Margaret C. Etter, Leslie Leiserowitz, The Role of Hydrogen Bonding in Molecular Assemblies Structure Correlation. pp. 431- 507 ,(1994) , 10.1002/9783527616091.CH11
Mehran Yazdanian, Susan L. Glynn, James L. Wright, Amale Hawi, Correlating Partitioning and caco-2 Cell Permeability of Structurally Diverse Small Molecular Weight Compounds Pharmaceutical Research. ,vol. 15, pp. 1490- 1494 ,(1998) , 10.1023/A:1011930411574
Iain DH Oswald, David R Allan, Pamela A McGregor, WD Samuel Motherwell, Simon Parsons, Colin R Pulham, None, The formation of paracetamol (acetaminophen) adducts with hydrogen-bond acceptors Acta Crystallographica Section B-structural Science. ,vol. 58, pp. 1057- 1066 ,(2002) , 10.1107/S0108768102015987
S. Nakao, S. Fujii, T. Sakaki, K. I. Tomita, The crystal and molecular structure of the 2:1 molecular complex of theophylline with phenobarbital Acta Crystallographica Section B Structural Crystallography and Crystal Chemistry. ,vol. 33, pp. 1373- 1378 ,(1977) , 10.1107/S0567740877006116
R.N. Rai, K.B.R. Varma, Phase diagram and dielectric studies of binary organic materials Materials Letters. ,vol. 44, pp. 284- 293 ,(2000) , 10.1016/S0167-577X(00)00046-X
Peddy Vishweshwar, Ashwini Nangia, Vincent M. Lynch, Molecular Complexes of Homologous Alkanedicarboxylic Acids with Isonicotinamide: X-ray Crystal Structures, Hydrogen Bond Synthons, and Melting Point Alternation Crystal Growth & Design. ,vol. 3, pp. 783- 790 ,(2003) , 10.1021/CG034037H