The formation of paracetamol (acetaminophen) adducts with hydrogen-bond acceptors

摘要: The crystal structures of five hemiadducts paracetamol with 1,4-dioxane, N-methylmorpholine, morpholine, N,N-dimethylpiperazine and piperazine a related 1:1 adduct 4,4′-bipyridine are described. All characterized by the formation chains molecules, which linked via either OH⋯O=C interactions [C(9) in graph-set notation] or NH⋯O=C [C(4) chains], depending on presence absence substituent groups guest molecule. In all cases except for morpholine bipyridine adducts these connected hydrogen-bond reside crystallographic inversion centres. this linkage also involves π-stacking interaction; it is formed between OH two opposed molecules. Most (that an exception) decompose heating to give monoclinic paracetamol. This first systematic study series co-crystals containing