Genotoxic Evaluation of Surfactin C in Chinese Hamster Lung Cell Line.
作者： Jong-Hwan Lim , In-Bae Song , Byung-Kwon Park , Myoung-Seok Kim , Youn-Hwan Hwang
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摘要: To investigate the mutation inducibility of surfactin C, we performed chromosome aberration assay with Chinese hamster lung cells in vitro. The colorimetric MTT screening was carried out to determine cytotoxicity index (IC50) C. IC50 value 125 μg/ml. For test maximum concentration employed as μg/ml, followed by 62.5 and 31.25 μg/ml for lower concentrations, or without metabolic activation (S9). Cyclophosphamide mitomycin C were used positive controls presence absence S9 activation, respectively. These results showed that not capable inducing aberration, measured using cell line. There is no evidence have a genotoxic potential.
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