Surfactin C inhibits the Lipopolysaccharide-induced Transcription of Interleukin-1β and Inducible Nitric Oxide Synthase and Nitric Oxide Production in Murine RAW 264.7 Cells
作者： Mi-Hyun Hwang , Jong-Hwan Lim , Hyo-In Yun , Man-Hee Rhee , Jae-Youl Cho
DOI: 10.1007/S10529-005-2515-1
关键词:
摘要: The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 microg ml(-1))-treated mouse RAW 264.7 cells. LPS increased mRNA transcription cyclooxygenase (COX)-2, interleukin (IL)-1beta and inducible nitric oxide synthase (iNOS). However, at 50 ml(-1 )inhibited LPS-induced increase IL-1beta iNOS (NO) production a dose-dependent manner.
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