Chemical carcinogenesis, mutagenesis, and teratogenesis.
作者： P J O'Brien , Y Yamazoe , B F Hales , A Castonguay , P D Josephy
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摘要: Un symposium international intitule Chemical Carcinogenesis, Mutagenesis and Teratogenesis : a Tribute to James Elizabeth Miller eu lieu Toronto, Ont., le 19 juillet 1994, en presence de Miller. Miller, 79 ans, et son epouse (1920-1987) sont consideres comme les pionniers ce domaine recherche toxicologie experimentale medicale. En regle generale, la sensibilite des etres humains teratogenese ou carcinogenese chimiques est tres variable, dependant constitution genetique, du regime alimentaire, style vie l'exposition dans l'environnement. L'un objectifs ete d'examiner role enzymes mises jeu l'activation detoxication metaboliques carcinogenes teratogenes. Les variabilites interindividuelles taux ainsi que l'activite ces pourraient influencer l'humain aux teratogenes chimiques. Des observations experimentales indiquent glutation (GSH) S-transferases classe θ activent dihalomethanes qu'ils aussi declencher reponse carcinogene au butadiene 1,2-dibromo-3-chloropropane. Le spectaculaire polymorphisme genetique cette GSH pourrait jouer un carcinogenes. Similairement, l'embryon sac vitellin, qui constitue durant l'organogenese, etre important facteur determination teneurs cytochromes P450 1A2, amines aromatiques N-acetyltransferases sulfotransferases determiner arylamines De plus, une souche mise point par test d'Ames afin d'exprimer tant l'amine aromatique N-acetyltransferase cytochrome 1A2 humain decrite. Cette devrait s'averer utile pour identifier potentiellement humains. anti-inflammatoires non steroidiens utiles inhiber nitrosamine contenue fumee tabac associee cancer poumon. Enfin, isoformes metabolique ont identifiees.
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