Theoretical models of conformational transitions and ion conduction in voltage-dependent ion channels : Bioferroelectricity and superionic conduction

摘要: Theoretical studies of the structure and function ion channels are reviewed, with emphasis on underlying physical phenomena. Nerve muscle membranes exhibit behavior interpretable as ferroelectric: Studies show that conformational transitions in voltage-dependent can be understood terms from a ferroelectric state to superionically conducting state. The ferroelectric-superionic transition hypothesis is supported by observations voltage-gated conduction, surface charge, hysteresis, pyroelectricity, piezoelectricity, temperatures Curie-Weiss these channels. Macroscopically, opening sodium (Na+) channel appears involve moving phase boundary traveling outer inner axonal membrane. Molecular biology electrophysiology have provided partial picture microscopic Na+ channel, demonstrating pattern charged residues suggests “voltage sensor” role for f...