Modelling the role of intrinsic electric fields in microtubules as an additional control mechanism of bi-directional intracellular transport.

摘要: Active transport is essential for cellular function, while impaired has been linked to diseases such as neuronal degeneration. Much long distance in cells uses opposite polarity molecular motors of the kinesin and dynein families move cargos along microtubules. It clear that many types cargo are moved by both sets motors, frequently a reverse direction. The general question how direction regulated still open. mechanism cell’s differential control diverse within same cytoplasmic background unclear answer endosomes mitochondria different locations cell. To these questions we postulate existence local signaling used cell specifically cargos. In particular, propose an additional physical works through use constant alternating intrinsic (endogenous) electric fields means controlling speed microtubule-based transport. A specific model proposed analyzed this paper. involves rotational degrees freedom C-termini tubulin, their interactions coupling between elastic dielectric freedom. Viscosity solution also included resultant equation motion found nonlinear elliptic with dissipation. particular analytical obtained form kink whose properties analyzed. concluded can be modulated presence hence may correspond observed behavior motor protein