Gastrin and Gastric Cancer

摘要: Gastric cancer although occurring in reduced frequency, is still an important disease, partly because of the bad prognosis when western countries. This decline occurrence may mainly be due to prevalence Helicobacter pylori (Hp) infection, which most cause gastric cancer. There exist many different pathological classifications carcinomas, but useful seems one by Lauren into intestinal and diffuse types since these seldom transform other also have epidemiology. During nearly 30 years that passed ground-breaking description Hp as gastritis cancer, a continuous search for mechanism infection causes has been done. Interestingly, it atrophic oxyntic mucosa predisposes possibly inducing hypoacidity hypergastrinemia. are arguments favor role gastrin its target cell, enterochromaffin like (ECL) carcinogenesis. The carcinogenesis implies caution long-term treatment with inhibitors acid secretion secondary hypergastrinemia, common disease gastroesophageal reflux disease.