Curcumin suppresses gastric cancer by inhibiting gastrin-mediated acid secretion.
作者： Shufen Zhou , Dongjie Yao , Ling Guo , Ling Teng
关键词:
摘要: Hyperacidity in the stomach is known to promote progression of gastric cancer. The plant-derived chemotherapeutic curcumin used treat objective this study was investigate whether regulates gastrin-mediated acid secretion suppressing Gastric cancer cells were treated with 25 μm curcumin, followed by Annexin V/propidium iodide double-staining assay evaluate cell apoptosis. Western blot analysis analyze caspase-3 expression response treatment. Gastrin levels culture medium also monitored. Mice bearing cancers tumor expression, pH, and serum. Curcumin prominently inhibited proliferation promoted Caspase-3 upregulated reduced gastrin secretion. dramatically growth, increased In cancer, suppresses secretion, which inhibits progression.
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