Adenosine: Direct and Indirect Actions on Gastric Acid Secretion.

摘要: Composed by a molecule of adenine and ribose, adenosine is paradigm recyclable nucleoside with multiplicity functions that occupies privileged position in the metabolic regulatory contexts. Adenosine formed continuously intracellular extracellular locations all tissues. Extracellular signaling molecule, able to modulate vast range physiologic responses many cells organs, including digestive organs. The A1, A2A, A2B, A3 receptors are P1 purinergic receptors, G protein-coupled proteins implicated tissue protection. This review focused on gastric acid secretion, process centered parietal cell stomach, which contains large amounts H+/K+-ATPase, proton pump responsible for extrusion during secretion. Gastric secretion regulated an extensive collection neural stimuli endocrine paracrine agents, act either directly at membrane or indirectly through other mucosa, as well mechanic chemic stimuli. In this review, after briefly introducing these points, we condense current body knowledge about modulating action pathophysiology update its significance based recent findings mucosa humans animal models.