Inflammatory response in the acute phase of deep vein thrombosis

摘要: Objective: Deep vein thrombosis (DVT) is a multifactorial disease. Recently, inflammation has been suggested as risk factor for DVT. The question whether cause of venous or rather result the thrombotic process. Methods: We studied inflammatory response in acute phase DVT with interleukin-6, interleukin-8, and C-reactive protein (CRP) markers. Plasma concentrations were measured on day admission (day 0) 40 patients confirmed phlebography 33 clinical suspicion but negative results (controls). In DVT, markers also examined five subsequent days. Results: On 0, median plasma CRP 15.0 pg/mL (range, <3 to 70 pg/mL), 7.0 76 37.5 mg/L <7 164 mg/L), respectively, patient group less than 3 11 pg/mL; P < .001), 6.0 52 = .08), 5.0 pg/L 66 pg/L; controls. During next days, interleukin-6 concentration showed gradual decline from 5.5 (P interleukin8 was relatively constant time, declined 21.5 .01). Conclusion: Our data show an apparent highest decrease during This supports hypothesis that elevated are thrombosis. (J Vasc Surg 2002;35:701-6.)