A novel small-molecule PPI inhibitor targeting integrin αvβ3-osteopontin interface blocks bone resorption in vitro and prevents bone loss in mice.
作者： Doori Park , Chan-Won Park , YoungJin Choi , Jingjing Lin , Dong-Hyun Seo
DOI: 10.1016/J.BIOMATERIALS.2016.05.007
关键词:
摘要: Small molecule-inhibition targeting protein-protein interaction (PPI) is now recognized as an emerging and challenging area in drug design. We developed a novel interactive drug …
elsevier.com
sci-hub.se 参考文章(62)
Michael A. Horton, The αvβ3 integrin “vitronectin receptor” The International Journal of Biochemistry & Cell Biology. ,vol. 29, pp. 721- 725 ,(1997) , 10.1016/S1357-2725(96)00155-0
Z R Gan, R J Gould, J W Jacobs, P A Friedman, M A Polokoff, Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus. Journal of Biological Chemistry. ,vol. 263, pp. 19827- 19832 ,(1988) , 10.1016/S0021-9258(19)77710-2
J E Fisher, M P Caulfield, M Sato, H A Quartuccio, R J Gould, V M Garsky, G A Rodan, M Rosenblatt, Inhibition of osteoclastic bone resorption in vivo by echistatin, an "arginyl-glycyl-aspartyl" (RGD)-containing protein. Endocrinology. ,vol. 132, pp. 1411- 1413 ,(1993) , 10.1210/ENDO.132.3.8440195
S. L. Teitelbaum, Bone Resorption by Osteoclasts Science. ,vol. 289, pp. 1504- 1508 ,(2000) , 10.1126/SCIENCE.289.5484.1504
Eung-Yoon Kim, Ji Young Bang, Soo-Ik Chang, In-Cheol Kang, A novel integrin α5β1 antagonistic peptide, A5-1, screened by Protein Chip system as a potent angiogenesis inhibitor Biochemical and Biophysical Research Communications. ,vol. 377, pp. 1288- 1293 ,(2008) , 10.1016/J.BBRC.2008.10.166
Ichiro Nakamura, Lorraine Lipfert, Gideon A. Rodan, Le T. Duong, Convergence of αvβ3Integrin–And Macrophage Colony Stimulating Factor–Mediated Signals on Phospholipase Cγ in Prefusion Osteoclasts Journal of Cell Biology. ,vol. 152, pp. 361- 373 ,(2001) , 10.1083/JCB.152.2.361
Mone Zaidi, Skeletal remodeling in health and disease. Nature Medicine. ,vol. 13, pp. 791- 801 ,(2007) , 10.1038/NM1593
Richard A. Friesner, Jay L. Banks, Robert B. Murphy, Thomas A. Halgren, Jasna J. Klicic, Daniel T. Mainz, Matthew P. Repasky, Eric H. Knoll, Mee Shelley, Jason K. Perry, David E. Shaw, Perry Francis, Peter S. Shenkin, Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. Journal of Medicinal Chemistry. ,vol. 47, pp. 1739- 1749 ,(2004) , 10.1021/JM0306430
Paul J Kostenuik, Hung Q Nguyen, James McCabe, Kelly S Warmington, Carol Kurahara, Ning Sun, Ching Chen, Luke Li, Russ C Cattley, Gwyneth Van, Shelia Scully, Robin Elliott, Mario Grisanti, Sean Morony, Hong Lin Tan, Frank Asuncion, Xiaodong Li, Michael S Ominsky, Marina Stolina, Denise Dwyer, William C Dougall, Nessa Hawkins, William J Boyle, William S Simonet, John K Sullivan, Denosumab, a Fully Human Monoclonal Antibody to RANKL, Inhibits Bone Resorption and Increases BMD in Knock‐In Mice That Express Chimeric (Murine/Human) RANKL Journal of Bone and Mineral Research. ,vol. 24, pp. 182- 195 ,(2009) , 10.1359/JBMR.081112
Gregory R. Mundy, Osteoporosis and inflammation. Nutrition Reviews. ,vol. 65, pp. 147- 151 ,(2007) , 10.1111/J.1753-4887.2007.TB00353.X