Comparative sensitivity of commercially available aPTT reagents to mulga snake (Pseudechis australis) venom

摘要: This study aimed to determine the relative sensitivity of activated partial thromboplastin time (aPTT) reagents anticoagulant effects phospholipases in mulga snake (Pseudechis australis) venom.Twenty-one haematology laboratories participating Royal College Pathologists Australasia Quality Assurance Programs were sent human plasma samples spiked with venom (n=25 total results). Results for 17 patients envenoming available through Australian Snakebite Project.Only 12 25 returned an abnormally prolonged aPTT. Tests performed Dade Actin FS (n=7) did not identify any as abnormal. Although clotting times significantly using lupus sensitive FSL (n=5, p=0.043), only one was reported Only TriniCLOT aPTT S (n=6), HemosIL APTT SP (n=2) and Stago PTT-A (n=1) consistently recorded sample being above upper normal reference interval. Abnormally aPTTs four eight whose tests FSL, five HS, three S.We conclude that some used routine testing are relatively insensitive venom. these should be interpreted caution.