Involvement of protein kinase C‐δ in DNA damage‐induced apoptosis
作者： Alakananda Basu
DOI: 10.1111/J.1582-4934.2003.TB00237.X
关键词:
摘要: Apoptosis is a highly orchestrated cell suicidal program required to maintain balance between proliferation and death. A defect in apoptotic machinery can cause cancer. Many anticancer drugs are known kill tumor cells by inducing apoptosis, apoptosis lead drug resistance. regulated complex cellular signaling network. Several members of the protein kinase C (PKC) family serve as substrates for caspases PKCdelta isozyme has been intimately associated with DNA damage-induced apoptosis. It act both upstream downstream caspases. In response stimuli, full-length catalytic fragment may translocate distinct compartments, including mitochondria nucleus, reach their targets. Both activation intracellular distribution have significant impact on This review intends assimilate recent views regarding involvement
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