miRNAs: roles and clinical applications in vascular disease

摘要: miRNAs are small, endogenously expressed noncoding RNAs that regulate gene expression, mainly at the post-transcriptional level, via degradation or translational inhibition of their target mRNAs. Functionally, an individual miRNA can expression multiple genes. The study is rapidly growing and recent studies have revealed a significant role in vascular biology disease. Many highly vasculature, dysregulated diseased vessels. Several been found to be critical modulators pathologies, such as atherosclerosis, lipoprotein metabolism, inflammation, arterial remodeling, angiogenesis, smooth muscle cell regeneration, hypertension, apoptosis, neointimal hyperplasia signal transduction pathways. Thus, may serve novel biomarkers and/or therapeutic targets for This article summarizes current related disease correlations functional roles system discusses potential applications