Mucinous Colorectal Adenocarcinoma: Influence of EGFR and E-Cadherin Expression on Clinicopathologic Features and Prognosis.

摘要: Previous studies have shown conflicting results on epidermal growth factor receptor (EGFR) and E-cadherin expression in colorectal carcinoma their prognostic significance. To the best of our knowledge, this study is first to investigate EGFR expression, interrelation relation clinicopathologic, histologic parameters, survival rare mucinous adenocarcinoma (MA). In study, we studied tumor tissue specimens from 150 patients with MA nonmucinous (NMA). High-density manual microarrays were constructed using modified mechanical pencil tips technique, immunohistochemistry for was performed. All relations analyzed established statistical methodologies. NMA expressed significantly higher rates significant heterogenous pattern than MA. positivity interrelated both groups. group, high associated old age, male sex, multiplicity tumors, lack component, association schistosomiasis. However, only age subtype rather signet ring subtype. Conversely, cases fungating configuration, subtype, negative intratumoral lymphocytic response. cases, none these factors statistically significant. a univariate analysis, neither nor showed impact disease-free or overall survival. Targeted therapy against may not be useful Neither an independent