Prognostic significance of HER3 and HER4 protein expression in colorectal adenocarcinomas
作者： Panteleimon Kountourakis , Kitty Pavlakis , Amanda Psyrri , Dimitra Rontogianni , Nikolaos Xiros
关键词: Colorectal cancer 、 Protein expression 、 Surgical oncology 、 Cellular localization 、 Pathological 、 Immunohistochemistry 、 Staining 、 Pathology 、 Medicine 、 Lymph
摘要: Colorectal cancer remains a major cause of mortality in the Western world. A limited number studies has been conducted respect Her-3 and Her-4 expression their correlation with clinical parameters prognosis colorectal carcinomas . In this study we sought to determine pattern prognostic significance HER-3 HER-4 adenocarcinoma. We studied protein in106 paraffin embedded specimens primary tumors using immunohistochemistry. The levels were correlated several pathological parameters. staining displayed membranous cytoplasmic 18 (17%) 30 samples (28,3%), respectively. was found 20 (18,9%) 32 (30,2%), Specimens regarded as positive for associated moderate tumor grade (p = 0,032) older median age 0,010). involved lymphnodes 0,0003). Similar results obtained when considering irrespective cellular localization. There no between patients outcome. predict lymph nodes positivity cohort cancer.HER-4 status may identify aggressive biological behavior increased metastatic potential.
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