Plasma pharmacokinetics and tissue distribution of [6]‐gingerol in rats

摘要: [6]-Gingerol is one of the pungent components in ginger which has been found to possess various pharmacological effects. However, there insufficient information on properties [6]-gingerol based controlled pharmacokinetic studies. The aim this study was clarify distribution profiles blood and biological tissues experimental rats. Rats were administered a 240 mg/kg dose Gs (a extract, containing 53% [6]-gingerol) by oral ingestion. Plasma samples collected at 2.5, 5, 7.5, 10, 15, 20, 30, 45 min, 1, 1.5, 2, 3, 4 h after dosing (eight per time point), brain, heart, lung, spleen, liver, kidney, stomach small intestine 30 min (five animals point). Samples prepared liquid-liquid extraction procedure extracts assayed HPLC-UV. After application, absorbed rapidly into plasma, maximal concentration (4.23 µg/ml) reached 10 min post dosing. plasma concentrations declined with biexponential pattern. elimination half-time terminal phase 1.77 h apparent total body clearance 40.8 l/h. When orally, well distributed examined, highest gastrointestinal tract. Maximal most 0.5 h post-dosing. all higher than corresponding tissue ratios greater 1 0.25 h post-dose, showing high partitioning extensive distribution. Copyright © 2008 John Wiley & Sons, Ltd.