Sharp Wave Ripples during Visual Exploration in the Primate Hippocampus.

摘要: Hippocampal sharp-wave ripples (SWRs) are highly synchronous oscillatory field potentials that thought to facilitate memory consolidation. SWRs typically occur during quiescent states, when neural activity reflecting recent experience is replayed. In rodents, also brief locomotor pauses in maze exploration, where they appear support learning experience. this study, we detected occurred but goal-directed visual exploration nonhuman primates (Macaca mulatta). The exploratory showed peak frequency bands similar those of SWRs, and both types were inhibited at the onset their respective behavioral epochs. apparent contrast rodent these active periods e.g., while animals searched for a target object scene. associated with smaller saccades longer fixations. Also, coincided target-object fixations search, detection was more likely than events decoupled. Although observed high gamma-band only accompanied greater spiking synchrony populations. These results reveal not limited off-line states as conventionally defined; rather, informative performance windows. SWR an infrequent occurrence active, attentive performance, which may indicate new, extended role primates. SIGNIFICANCE STATEMENT Sharp-wave high-frequency oscillations generate synchronized Their prevalence sleep quiet wakefulness, deficits result from interruption, suggest contribute consolidation rest. Here, report monkey hippocampus inactivity successful exploration. attentive, focal search appeared enhance perception locations viewed around time occurrence. occurring rest noteworthy relation heightened population activity, temporally precise widespread synchronization, consolidation; therefore, reported here have effect on populations, even experiences unfold.