Positive association between a polymorphic locus near the LBX1 gene and predisposition of idiopathic scoliosis in Southeastern European population

摘要: Idiopathic scoliosis (IS) is a common medical condition in children, characterized by three-dimensional spinal curve and strong evidence of genetic predisposition. The purpose the present case-control study to examine association between polymorphic variant rs11190870 (T/C), near LBX1 gene, IS predisposition distinct subgroups based on age at onset, family history gender. A total 127 patients 254 unrelated controls Southeastern European descent were recruited. genotyping was carried out TaqMan real-time amplification technology. results analyzed Pearson's Chi-squared Test Fisher's Exact with value p less than 0.05 as statistically significant. T allele homozygous TT genotype associated greater incidence IS. Our suggest that there adolescents, familial non-familial cases, females. Larger studies are necessary factors IS/AIS etiology infants, juveniles males. In conclusion, molecular identification diagnostic prognostic markers would make an early treatment including minimally invasive procedures possible.