Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia: impact of the 11q23 breakpoint on outcome: a report of the Childrens Cancer Group

摘要: Abstract Cytogenetic analyses of pretreatment bone marrows were performed at local institutions as part Childrens Cancer Group (CCG) protocol CCG-107 for infants less than 1 year age with previously untreated acute lymphoblastic leukemia (ALL). from 39 patients (17 males and 22 females) accepted after review. Several unique cytogenetic features observed. Twelve (31%) had a t(4;11)(q21;q23) significantly shorter event-free survival (EFS) did the other adequate (P= .009). Five additional an 11q23 breakpoint, not associated 4q21. When EFS these 5 was compared that t(4;11) patients, even small numbers there strong, although significant, suggestion have reduced (P = .09), indicating specific translocation, t(4;11)(q21;q23), breakpoint per se, may be poor prognosis infants. Structural abnormalities present in 27 28 abnormal karyotypes. A new recurring abnormality, t(5;15)(p15.1;q11) or t(5;15)(p15.3;q13), identified 3 (Arthur et al. Blood 70:274a, 1987 [abstr, suppl 1]). Two females structural involving Xp11, rarely seen ALL. Fourteen (36%) single 13 (33%) complex No hyperdiploidy more 50 chromosomes. Only normal chromosomes observed 11 (28%), their outcome differ These found leukemic cells are clearly different those older children adults, explain, part, biologic characteristics infant