Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification

摘要: Many compounds and genetic manipulations are claimed to confer resistance obesity in rodents by raising energy expenditure. Examples taken from recent older literature, demonstrate that such claims often based on measurements of expenditure after body composition has changed, depend comparisons divided weight. This is misleading because white adipose tissue less influence than lean Application this approach human data would suggest usually due a low metabolic rate, which not an accepted view. Increased per animal surer way demonstrating thermogenesis, but even then it important know whether altered (repartitioning), or increased locomotor activity rather thermogenesis se. Regression analysis offers other approaches. The thermogenic response some rapid onset so cannot be composition. These mimic activate the sympathetic nervous system. Thermogenesis occurs in, may confined to, brown tissue. It should assumed weight loss these treatments unless there sustained increase 24-h Thyroid hormones fibroblast growth factor 21 also raise before they affect Some modifications alter diurnal rhythm establish efficiency locomotion. There no good examples do short-term have delayed effect. How under what conditions modification compound increases influences decision seek drugs for target take candidate drug into clinical studies.