Modulation of mitogenesis by liver fatty acid binding protein

作者: Sam Sorof

DOI: 10.1007/BF00666102

关键词:

摘要: Liver fatty acid binding protein (L-FABP), a cytoplasmic 14 kDa previously termed Z protein, is conventionally considered to be an intracellular carrier of acids in rat hepatocytes. The following evidence now indicates that L-FABP also specific mediator mitogenesis hepatocytes: These actions are consistent with those involved regulation hepatocyte multiplication. Discovery L-FABP, the target two types genotoxic carcinogens, required for induced by classes nongenotoxic carcinogens points common process which both groups promote implication during tumor promotion liver carcinogenesis, these and modify normal LFABP, functioning as receptor unsaturated or their metabolites, promotes multiplication

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