Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment

摘要: The tumor suppressor p53 regulates genes involved in DNA repair, metabolism, cell cycle arrest, apoptosis and senescence. is mutated about 50% of the human cancers, while tumors with wild-type gene, protein function may be lost because overexpression Murine Double Minute 2 (MDM2). MDM2 targets for ubiquitylation proteasomal degradation. reactivation through inhibitors seems to a promising strategy sensitize cancer cells apoptosis. Moreover, additional p53-independent molecular functions MDM2, such as neoangiogenesis promotion, have been suggested. Thus, might target anticancer treatment its antiapoptotic proangiogenetic role. Malignant pleural mesothelioma (MPM) an aggressive asbestos-related where present. present review gives complete landscape role pathogenesis, prognosis treatment, particular focus on Pleural Mesothelioma.