Immunohistochemical markers for prognosis of cerebral glioblastomas.

摘要: Glioblastoma is the commonest neuroectodermal tumor and most malignant in range of cerebral astrocytic gliomas. The prognostic utility various biological markers for glioblastomas has been broadly tested but results obtained are regarded as controversial. In present study, 302 glioblastoma specimens were studied to evaluate a possible association between clinical outcome expression some immunohistochemical variables. Furthermore, tumors examined subdivided on three cytological subsets – small-cell (SGB), pleomorphic-cell (PGB) gemistocytic (GGB). Immunohistochemical variables differed subsets: number p53-positive was found be prevailed among PGB, whereas with EGFR mdm2 positivity significantly greater SGB. GGB contained lowest mean proliferating cell nuclear antigen (PCNA) labeling index (LI), p21ras positive cases, higher apoptotic (AI). Survival time patients SGB, mdm2-positivity PCNA LI >40% shorter, presence AI >0.5% associated prolonged survival. Multivariate analysis revealed that survival EGFR-positivity, (p = 0.0023, p 0.0035 0.0029 respectively). We conclude although significant outcome, they appear closely related biology single subsets. these exhibited no value when analyzed within each subset separately. Therefore, subdivision proposed by us carrying element rationality but, undoubtedly, requires further prospective studies.