Distribution of epidermal growth factor receptor gene amplification in brain tumours and correlation to prognosis
作者： Uwe Diedrich , Jens Lucius , Eleonore Baron , Julianne Behnke , Brigitte Pabst
DOI: 10.1007/BF00866920
关键词:
摘要: In 75 gliomas and 31 meningiomas, mutations at the epidermal growth factor receptor (EGFR) gene locus were restricted to gliomas. The ligands of this receptor, transforming alpha, lacked quantitative changes their loci in meningiomas. EGFR amplification occurred astrocytomas, oligodendrogliomas, ependymomas glioblastomas. frequency mutation significantly increased with malignancy grade patient's age. Especially glioblastomas individuals aged over 64 years, observed without chromosome-10-specific allele losses. This finding contradicts hypothesis that deletion one entire chromosome 10 regularly precedes primary patients 50 years. It was found most whose carry an have a poor prognosis, comparable glioblastoma even when tumour is graded as benign.
springer.com
sci-hub.se 参考文章(19)
Ralf F. Pettersson, A. Jonas Ekstrand, C. David James, V. Peter Collins, V. Peter Collins, Barbara Seliger, Webster K. Cavenee, Genes for Epidermal Growth Factor Receptor, Transforming Growth Factor α, and Epidermal Growth Factor and Their Expression in Human Gliomas in Vivo Cancer Research. ,vol. 51, pp. 2164- 2172 ,(1991)
Towia A. Libermann, Harris R. Nusbaum, Nissim Razon, Richard Kris, Irit Lax, Hermona Soreq, Nigel Whittle, Michael D. Waterfield, Axel Ullrich, Joseph Schlessinger, Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin Nature. ,vol. 313, pp. 144- 147 ,(1985) , 10.1038/313144A0
J.C. Murray, K.H. Buetow, G.I. Bell, RFLPs for transforming growth factor alpha (TGFA) gene at 2p13 Nucleic Acids Research. ,vol. 14, pp. 7136- 7136 ,(1986) , 10.1093/NAR/14.17.7136
Magnus Nordenskj�ld, Catharina Larsson, A.Elisabeth Karlbom, C.David James, J�rgen Boethius, WebsterK. Cavenee, V.Peter Collins, Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10. Human Genetics. ,vol. 92, pp. 169- 174 ,(1993) , 10.1007/BF00219686
T. Bragg, Y. Nakamura, C. Jones, R. White, Isolation and mapping of a polymorphic DNA sequence (cTBQ7) on chromosome 10 [D10S28]. Nucleic Acids Research. ,vol. 16, pp. 11395- 11395 ,(1988) , 10.1093/NAR/16.23.11395
K. Watanabe, M. Nagai, S. Wakai, T. Arai, K. Kawashima, Loss of constitutional heterozygosity in chromosome 10 in human glioblastoma Acta Neuropathologica. ,vol. 80, pp. 251- 254 ,(1990) , 10.1007/BF00294641
J. C. Murray, C. R. DeHaven, G. I. Bell, RFLPs for epidermal growth factor (EGF), a single copy sequence at 4q25-4q27. Nucleic Acids Research. ,vol. 14, pp. 5117- 5117 ,(1986) , 10.1093/NAR/14.12.5117
Mark R. Hurt, John Moossy, Maryann Donovan-Peluso, Joseph Locker, Amplification of epidermal growth factor receptor gene in gliomas: histopathology and prognosis. Journal of Neuropathology and Experimental Neurology. ,vol. 51, pp. 84- 90 ,(1992) , 10.1097/00005072-199201000-00010
Young-hua Xu, Shunsuke Ishii, Adrian J. L. Clark, Margery Sullivan, Richard K. Wilson, Din Pow Ma, Bruce A. Roe, Glenn T. Merlino, Ira Pastan, Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells. Nature. ,vol. 309, pp. 806- 810 ,(1984) , 10.1038/309806A0
Uwe Diedrich, Sabine Soja, Julianne Behnke, Barbara Zoll, Amplification of the c-erbB oncogene is associated with malignancy in primary tumours of neuroepithelial tissue. Journal of Neurology. ,vol. 238, pp. 221- 224 ,(1991) , 10.1007/BF00314785