Procalcitonin and the inflammatory response to salt in essential hypertension: a randomized cross-over clinical trial.

摘要: Objectives: Inflammation is considered as a major effector of arterial damage brought about by salt excess in animal models. In randomized, single masked, cross-over study 32 uncomplicated essential hypertensive patients, we assessed the effect short-term low-salt diet on biomarkers innate immunity [procalcitonin (PCT), interleukin-6, C-reactive protein, and tumor necrosis factor-a (TNF-a)], adiponectin (ADPN, an anti-inflammatory cytokine), leptin. Methods: Patients were randomized to either 10–20mmol sodium tablets (180mEq/day) achieve 200mmol intake per day or same identical placebo tablets, each for 2 weeks. At end these periods, all patients underwent 24-h urine collection, fasting blood sampling, 24h ambulatory pressure monitoring. Results: parallel with expected increase plasma renin activity aldosterone (P <0.001), both PCT (R33%) TNF-a (9%) rose at low � 0.007) while ADPN opposite change (� 17%, P <0.001). linear regression analysis repeated measurements, was significantly inversely related urinary (weighted r ¼� 0.27, ¼0.03). Changes inflammation did not differ salt-sensitive (n ¼7) salt-resistant ¼25) patients. Conclusion: very generates pro-inflammatory phenotype characterized cytokine like ADPN.