Intestinal taurine and the enterohepatic circulation of taurocholic acid in the cat.

摘要: Taurine’s most well defined role is the conjugation of bile salts in liver. After synthesis from cholesterol, are conjugated with taurine and/or glycine before secretion into canaliculi1. When limiting, mammals have ability to conjugate glycine, exceptions being dog2 and cat3,4, which almost exclusively taurine. The percentage total determined by both hepatic concentration affinity salt conjugase for taurine2,5-7. Taurine preferred substrate species 90 percent occurring rat when concentrations equal7. Hepatic depletion rats, caused infusion cholic acid7 or feeding guanidinoethanesulfonic acid5, results a substantial increase amount glycine. In that cannot (the dog cat), leads instead an proportion unconjugated salts, majority free acid2,3.