Icariin inhibits neurotoxicity of beta-amyloid by upregulating cocaine-regulated and amphetamine-regulated transcripts.
作者： Dujuan Sha , Lingling Li , Lan Ye , Rong Liu , Yun Xu
DOI: 10.1097/WNR.0B013E328332D345
关键词:
摘要: beta-Amyloid peptide (Abeta) is one of the main protein components senile plaques contributing to Alzheimer's disease and it can induce neuronal apoptosis. In this study, was found that icariin, a flavonoid extracted from Chinese Herba-Epimedii, inhibited Abeta42-induced neurotoxicity in dose-dependent manner. The peak dose icariin 160 microg/ml. addition, mRNA expressions cocaine amphetamine-regulated transcript (CART) were increased Abeta42-treated neurons presence 80 microg/ml icariin. Moreover, CART-RNA interference able reverse neuroprotection on Abeta42. Furthermore, expression CART be suppressed by extracellular signal-regulated kinase inhibitor instead p38/JNK inhibitors, suggesting may developed into therapeutic agents for other neurodegenerative diseases.
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