Icariin Ameliorates Neuropathological Changes, TGF-β1 Accumulation and Behavioral Deficits in a Mouse Model of Cerebral Amyloidosis
作者： Zhi-Yuan Zhang , Chaoyun Li , Caroline Zug , Hermann J. Schluesener
DOI: 10.1371/JOURNAL.PONE.0104616
关键词: Alzheimer's disease 、 Neuroprotection 、 Pharmacology 、 Icariin 、 Hippocampus 、 Genetically modified mouse 、 Brain damage 、 Amyloidosis 、 Immunology 、 Neuroinflammation 、 Biology 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Icariin, a major constituent of flavonoids from the Chinese medicinal herb Epimedium brevicornum, exhibits multiple biological properties, including anti-inflammatory, neuroregulatory and neuroprotective activities. Therefore, Icariin might be applied in treatment neurodegenerative disorders, Alzheimer's disease (AD), which is neuropathologically characterized by β-amyloid aggregation, hyperphosphorylated tau neuroinflammation. Potential therapeutic effects were investigated an animal model cerebral amyloidosis for AD, transgenic APP/PS1 mouse. was suspended carboxymethylcellulose given orally to mice. Therapeutic monitored behavioral tests, namely nesting assay, before during experimental treatment. Following oral 10 days, significantly attenuated Aβ deposition, microglial activation TGF-β1 immunoreactivity at amyloid plaques cortex hippocampus mice 5 months age, restored impaired ability. Our results suggest that considered promising option human AD.
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