Molecular study of Porcine Circovirus type 2 in wild boars and domestic pigs in Uruguay from 2010 to 2014: Predominance of recombinant circulating strains.

摘要: Porcine Circovirus type 2 (PCV2) is a worldwide distributed pathogen and one of the most economically relevant swine infections. Four genotypes have been recognized it well known that PCV2a, PCV2b PCV2d global distribution. However, information about recombinant strains circulation their influence in driving PCV2 evolution poorly studied area. In Uruguay, associated symptoms began to be frequently observed pigs from different farms since 2010. The main purpose this study was thoroughly investigate molecular epidemiology nationwide herds free-living wild boars during period 2010-2014, providing an extensive viral sequence dataset. Surprisingly, findings revealed predominance circulation, evidencing for first time field recombination can lead emergence able compete potentially displace parental ones. addition, (29%), (10.5%) PCV2a (7.9%) were also observed. Since 2013, high identified country probably reflected recent scenario genotype. fluctuations frequency infection evaluated may suggest limitation biosecurity strategies implemented Uruguay disease control, including instability vaccination practices. On other hand, sustained boar population similarity among circulating these animals domestic pigs, suggested could serve as permanent reservoir disease. Altogether, work put forward many factors play role heterogeneity rapid spread evolution, recombination, wide movement within national boundaries multiples introduction events resulting international trade. Continuous monitoring needed better understand dynamics development appropriate are required control.