Diethylcarbamazine citrate, an antifilarial drug, stimulates human granulocyte adherence.
作者： C H King , B M Greene , P J Spagnuolo
DOI: 10.1128/AAC.24.3.453
关键词:
摘要: Incubation with diethylcarbamazine citrate caused significant augmentation of human neutrophil and eosinophil adherence to tissue culture plastic. This effect was dose dependent cell dependent, eosinophils showing greater sensitivity a adhesive response the drug than did neutrophils. Eosinophils preincubated demonstrated decreased responses other adherence-augmenting stimuli. Use Fc-treated plastic augmented citrate-stimulated (but not eosinophil) adherence. Direct stimulation host effector may explain, in part, therapeutic action vivo.
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