Signal transduction: Clamping down on Src activity

作者: Bruce J. Mayer

DOI: 10.1016/S0960-9822(06)00141-2

关键词:

摘要: Recent high-resolution structures of members the Src family protein-tyrosine kinases illustrate how a series cooperative intramolecular interactions represses catalytic activity these kinases, but allows for their rapid activation by variety regulatory inputs.

参考文章(13)
G. Superti-Furga, S. Fumagalli, M. Koegl, S.A. Courtneidge, G. Draetta, Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src. The EMBO Journal. ,vol. 12, pp. 2625- 2634 ,(1993) , 10.1002/J.1460-2075.1993.TB05923.X
J B Levy, H Hanafusa, J Y Kato, T Takeya, C Grandori, H Iba, Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein. Molecular and Cellular Biology. ,vol. 6, pp. 4155- 4160 ,(1986) , 10.1128/MCB.6.12.4155
Philip D. Jeffrey, Alicia A. Russo, Kornelia Polyak, Emma Gibbs, Jerard Hurwitz, Joan Massagué, Nikola P. Pavletich, Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex Nature. ,vol. 376, pp. 313- 320 ,(1995) , 10.1038/376313A0
J. B. Levy, H. Iba, H. Hanafusa, Activation of the transforming potential of p60c-src by a single amino acid change. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 4228- 4232 ,(1986) , 10.1073/PNAS.83.12.4228
Tony Pawson, Protein modules and signalling networks Nature. ,vol. 373, pp. 573- 580 ,(1995) , 10.1038/373573A0
Wenqing Xu, Stephen C. Harrison, Michael J. Eck, Three-dimensional structure of the tyrosine kinase c-Src Nature. ,vol. 385, pp. 595- 602 ,(1997) , 10.1038/385595A0
Ismail Moarefi, Michelle LaFevre-Bernt, Frank Sicheri, Morgan Huse, Chi-Hon Lee, John Kuriyan, W. Todd Miller, Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement Nature. ,vol. 385, pp. 650- 653 ,(1997) , 10.1038/385650A0
Hiroto Yamaguchi, Wayne A. Hendrickson, Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation Nature. ,vol. 384, pp. 484- 489 ,(1996) , 10.1038/384484A0
Louise N Johnson, Martin E.M Noble, David J Owen, Active and Inactive Protein Kinases: Structural Basis for Regulation Cell. ,vol. 85, pp. 149- 158 ,(1996) , 10.1016/S0092-8674(00)81092-2
George B Cohen, Ruibao Ren, David Baltimore, Modular binding domains in signal transduction proteins Cell. ,vol. 80, pp. 237- 248 ,(1995) , 10.1016/0092-8674(95)90406-9