Ovine placentome morphology: Effect of high altitude, long-term hypoxia

摘要: Abstract The effect of high altitude, long-term hypoxaemia on placentome morphology in the sheep was examined using singleton and twin pregnant ewes. Normoxic twins had lower fetal placental weights (3.7 ± 0.2 kg 215 26 g, respectively) than normoxic fetuses (4.3 336 17 respectively). Fetal were similar altitude (3820 m) hypoxic 4.4 0.4 kg, 342 62 distribution types classified into four major categories (A-D) for singletons as follows: A=76 4, B=22 3, C=1 2, D=1 1. tended to have more type B (type A=63 10, B=33 8, C=2 1, D=2 1). High significantly fewer A (33 4) (50 3), C (10 7), D (7 1) placentomes singletons. In addition, sea-level control group, five animals found be spontaneously with a that fetuses. conclusion, both hypoxia low spontaneous lead significant change less increases B, D. Physiologically, several suggests an acclimatization response optimize transplacental exchange efficiency.