The mammary gland vasculature revisited.

摘要: Concomitant with the extensive growth and differentiation of mammary epithelium during pregnancy lactation, epithelial involution after weaning, vasculature gland undergoes repeated cycles expansion regression. Vascular is effected by sprouting angiogenesis, intussusception conceivably also vasculogenesis. The capacity cells to stimulate vascular dependent on constellation systemic local hormones factors as well changing demands for oxygenation nutrient supply. This results in release angiogenic which endothelial cell regulate architecture. In contrast phase cycle, little known about control regression although this would possibly offer new insights into therapeutic possibilities against breast cancer. review we summarize knowledge regarding mechanisms regulating delineate importance attainment organ function. addition, discuss observed carcinogenesis their consequences cancer therapy.