Photoluminescent polysaccharide-coated germanium(IV) oxide nanoparticles

摘要: In current biomedically oriented research, the development of a biomimetic nanoparticle platform is interest to provide molecular toolbox (i.e., allowing easy modular exchange its parts depending on actual needs while being nontoxic and real-time recognition tracking using various methods, such as fluorescence). We report germanium(IV) oxide-polysaccharide composite particles possessing these properties. The nanoparticles are based crystalline germanium oxide core with size range 20–30 300–900 nm. Two new simple coating techniques were compared for preparation photoluminescent polysaccharide-coated nanoparticles. germanium(IV)-based allows in situ polysaccharide attachment via direct chelation. addition, coated thin layer silicon oxide. After coating, 3-(triethoxysilyl)propyl isocyanate was grafted onto surface, polysaccharides immobilized particle surface covalent urethane linkage, which an even more stable than that obtained This approach provides access material biological track image applications.