Hypoxia in Mesenchymal Stem Cell

摘要: Mesenchymal stem cells (MSCs) are non-hematopoietic multipotent with selfrenewal properties and ability to differentiate into a variety of mesenchymal tissues. This chapter overviews effects hypoxia on MSCs, makes it promising therapy to various diseases. Cultivation MSCs under hypoxic condition results in of outcome that is important be noted clinical use. In most studies, condition appears increase proliferation, differentiation, immune regulatory performance of without affecting its characteristic. Those benefits therefore utilized in clinical application. However, there also studies report negative of hypoxia such as chromosomal instability. Molecular mechanism in hypoxic provided for better understanding, which crucial further development outcome.