Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension.

摘要: No consistent differential effects were observed for other outcomes (few studies reported long-term outcomes), including death, cardiovascular events, quality of life, rate single antihypertensive agent use, lipid levels, progression to diabetes, left ventricular mass or function, and kidney disease. Consistent fair- good-quality evidence showed that ACE inhibitors associated with a greater risk cough. There fewer withdrawals due adverse events persistence therapy ARBs than inhibitors, although this was not definitive. Patient subgroups whom more effective, better tolerated identified. Limitations: Few involved representative sample treated in typical clinical setting over long duration, treatment protocols had marked heterogeneity, substantive amounts data about important patient missing. Conclusion: Available shows have similar on blood pressure control, higher rates cough ARBs. Data regarding are limited.