Mitonuclear match: Optimizing fitness and fertility over generations drives ageing within generations

摘要: Many conserved eukaryotic traits, including apoptosis, two sexes, speciation and ageing, can be causally linked to a bioenergetic requirement for mitochondrial genes. Mitochondrial genes encode proteins involved in cell respiration, which interact closely with encoded by nuclear Functional respiration requires the coadaptation of genes, despite divergent tempi modes evolution. Free-radical signals emerge directly from biophysics mosaic respiratory chains genomes prone mismatch, apoptosis being default penalty compromised respiration. Selection genomic matching is facilitated optimizes fitness, adaptability fertility youth. Mismatches cause infertility, low hybrid breakdown, potentially speciation. The dynamics selection mitonuclear function optimize fitness over generations, but same selective processes also operate within driving ageing age-related diseases. This coherent view energetics offers striking insights into infertility