Meta-analyses of studies of the diagnostic accuracy of laboratory tests : A review of the concepts and methods

摘要: ○ Objective.-To provide practicing pathologists and other laboratory professionals with the necessary background for reading evaluating published reports of meta-analyses studies diagnostic accuracy tests. Study Selection.-English language literature, 1980 to present, pertaining rationale, objectives, interpretation randomized controlled trials, Conclusions.-Meta-analysis has several applications in investigation It can improve quality future primary by drawing attention methodologic deficiencies existing reports; it identify reasons variation results those generate valid summary estimates tests based on all completed investigations, providing that available are high scientific validity. Several statistical techniques integrating data from test have either been developed or under development, but meta-analysis is often limited poor effect publication bias. Meta-analysis evolve into a reliable tool assessing if both investigators editors strive reduce extent bias this area literature.