作者: Semir Vranic , Snjezana Frkovic-Grazio , Janez Lamovec , Fadila Serdarevic , Olga Gurjeva
DOI: 10.1016/J.HUMPATH.2010.04.013
关键词:
摘要: Adenoid cystic carcinoma of the breast is a rare subtype cancer with basal-like features. Published studies on adenoid are limited, resulting in relatively scarce information value predictive tumor markers. We studied 20 primary cases for expression estrogen receptor, progesterone androgen epidermal growth factor HER-2/neu, and topoisomerase IIα using immunohistochemistry fluorescent situ hybridization methods. Estrogen receptor were detected 1 case each. All tumors uniformly negative Her-2/neu expression. Androgen weakly positive three 7 cases, respectively. Epidermal overexpression was 13 (65% all cases). Amplification TOP2A or HER-2/neu gene not any cases. Our study shows that majority carcinomas do overexpress Her-2/neu, IIα, thus, they unlikely to respond therapies targeting these proteins. However, frequently over-express indicating potential benefit from anti-epidermal therapy patients advanced breast.