Identification of a candidate therapeutic autophagy-inducing peptide

摘要: The lysosomal degradation pathway of autophagy has a crucial role in defence against infection, neurodegenerative disorders, cancer and ageing. Accordingly, agents that induce may have broad therapeutic applications. One approach to developing such is exploit manipulation strategies used by microbial virulence factors. Here we show peptide, Tat-beclin 1-derived from region the protein, beclin 1, which binds human immunodeficiency virus (HIV)-1 Nef-is potent inducer autophagy, interacts with newly identified negative regulator GAPR-1 (also called GLIPR2). 1 decreases accumulation polyglutamine expansion protein aggregates replication several pathogens (including HIV-1) vitro, reduces mortality mice infected chikungunya or West Nile virus. Thus, through characterization domain HIV-1 Nef, developed an autophagy-inducing peptide potential efficacy treatment diseases.