Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.

摘要: Reciprocal interactions between B and follicular T helper (Tfh) cells orchestrate the germinal center (GC) reaction, a hallmark of humoral immunity. Abnormal GC responses could lead to production pathogenic autoantibodies development autoimmunity. Here we show that miR-146a controls by targeting multiple CD40 signaling pathway components in cells; contrast, loss does not alter responses. However, specific deletion both its paralog, miR-146b, increases Tfh cell numbers enhanced reactions. Thus, our data reveal differential cell-intrinsic regulations miR-146b. Together, members miR-146 family serve as crucial molecular brakes coordinately control reactions generate protective without eliciting unwanted