MicroRNA-153 promotes Wnt/β-catenin activation in hepatocellular carcinoma through suppression of WWOX.

摘要: // Hong-Wei Hua 1, * , Feng Jiang 2, Qian Huang 2 Zhijun Liao Gang Ding 1 Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200092, China Department Oncology, Chongming Branch, 202150, These authors have contributed equally this work Correspondence to: Ding, e-mail: dinggangcm@126.com Keywords: Hepatocellular carcinoma, β-catenin, MicroRNA, MicroRNA-153, WWOX Received: September 19, 2014      Accepted: December 16, Published: February 02, 2015 ABSTRACT Persistent activation Wnt/β-catenin signaling plays crucial roles in the development human cancers, including hepatocellular carcinoma (HCC). Here, we performed a MicroRNA-based genetic screen, which revealed novel diversion β-catenin triggered by MicroRNA-153 (miR-153). Overexpression miR-153 was able promote transcriptional activity, leading cell-cycle progression, proliferation and colony formation HCC cells. Additionally, systemic administration antigomir suppressed carcinogenesis murine liver cancer model. At molecular level, found that inhibited protein level WWOX, tumor suppressor inhibitor signaling, through targeting its 3'-untranslated region. Therefore, our study highlights importance MicroRNA-153/WWOX/β-catenin regulatory axis tumorigenesis.