Inhibition of the Wnt/β-catenin pathway by the WWOX tumor suppressor protein
作者： N Bouteille , K Driouch , P El Hage , S Sin , E Formstecher
DOI: 10.1038/ONC.2009.120
关键词:
摘要: The WWOX gene encodes a candidate tumor suppressor protein (WWOX) implicated in variety of human diseases such as cancer. To better understand the molecular mechanisms action, we investigated novel partners this protein. Using two-hybrid system and coimmunoprecipitation assay, observed physical association between Dishevelled (Dvl) family signaling elements involved Wnt/β-catenin pathway. We found that enforced expression inhibited, inhibition endogenous stimulated transcriptional activity Inhibition also enhanced effect Wnt-3a on β-catenin stability. Moreover, sequestration Dvl-2 wild type Dvl-2NESm, mutated form predominantly localized nucleus, cytoplasm compartment by WWOX. Our results indicate is inhibitor would act, at least part, preventing nuclear import Dvl proteins.
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Shosei Kishida, Hideki Yamamoto, Shin-ichiro Hino, Satoshi Ikeda, Michiko Kishida, Akira Kikuchi, DIX Domains of Dvl and Axin Are Necessary for Protein Interactions and Their Ability To Regulate β-Catenin Stability Molecular and Cellular Biology. ,vol. 19, pp. 4414- 4422 ,(1999) , 10.1128/MCB.19.6.4414
Keiji Itoh, Barbara K Brott, Gyu-Un Bae, Marianne J Ratcliffe, Sergei Y Sokol, Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling Journal of Biology. ,vol. 4, pp. 3- 3 ,(2005) , 10.1186/JBIOL20
Noriko Yokoyama, Dezhong Yin, Craig C Malbon, Abundance, complexation, and trafficking of Wnt/β-catenin signaling elements in response to Wnt3a Journal of Molecular Signaling. ,vol. 2, pp. 11- 11 ,(2007) , 10.1186/1750-2187-2-11
Karin Ried, Merran Finnis, Lynne Hobson, Marie Mangelsdorf, Sonia Dayan, Julie K Nancarrow, Erica Woollatt, Gabriel Kremmidiotis, Alison Gardner, Deon Venter, Elizabeth Baker, Robert I Richards, Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells Human Molecular Genetics. ,vol. 9, pp. 1651- 1663 ,(2000) , 10.1093/HMG/9.11.1651
Francesco Trapasso, Krittaya Sutheesophon, Teresa Druck, Yusuke Furukawa, Miki Nishimura, Hideshi Ishii, Kay Huebner, Tamotsu Kuroki, Keiya Ozawa, Andrea Vecchione, Yutaka Furukawa, Carlo M. Croce, Shuang Yin Han, Yasushi Saito, Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies. Molecular Cancer Research. ,vol. 1, pp. 940- 947 ,(2003)
Rami I. Aqeilan, Valentina Donati, Alexey Palamarchuk, Francesco Trapasso, Mohamed Kaou, Yuri Pekarsky, Marius Sudol, Carlo M. Croce, WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Research. ,vol. 65, pp. 6764- 6772 ,(2005) , 10.1158/0008-5472.CAN-05-1150
Stuart Naylor, David Cook, Hiran Jayatilake, Lee G. Fryer, Lisa Hutchinson, Michael J. Fry, Trevor C. Dale, Matthew J. Smalley, Elizabeth Sara, Hugh Paterson, Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription. The EMBO Journal. ,vol. 18, pp. 2823- 2835 ,(1999) , 10.1093/EMBOJ/18.10.2823
M. Fabbri, D. Iliopoulos, F. Trapasso, R. I. Aqeilan, A. Cimmino, N. Zanesi, S. Yendamuri, S.-Y. Han, D. Amadori, K. Huebner, C. M. Croce, WWOX gene restoration prevents lung cancer growth in vitro and in vivo Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 15611- 15616 ,(2005) , 10.1073/PNAS.0505485102
R. I. Aqeilan, Y. Pekarsky, J. J. Herrero, A. Palamarchuk, J. Letofsky, T. Druck, F. Trapasso, S.-Y. Han, G. Melino, K. Huebner, C. M. Croce, Functional association between Wwox tumor suppressor protein and p73, a p53 homolog Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 4401- 4406 ,(2004) , 10.1073/PNAS.0400805101
Shin-ichiro Hino, Shosei Kishida, Tatsuo Michiue, Akimasa Fukui, Ikuo Sakamoto, Shinji Takada, Makoto Asashima, Akira Kikuchi, Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Molecular and Cellular Biology. ,vol. 21, pp. 330- 342 ,(2001) , 10.1128/MCB.21.1.330-342.2001